Recent discoveries have suggested that aging is not because of any kind of molecular damage. It is not due to any random damage either. The relationship that exists between disease and aging is quite apparent. This is why Dr. Mikhail Blagosklonny likes to talk about it in more detail.
He says that in the case of cell culture, there may be times when the actual proliferation tends to get blocked. Even then, active pathways will still exist. This signals growth. Besides, these pathways are able to sense nutrients.
Dr. Mikhail Blagosklonny further clarifies this to include the Target of Rapamycin pathway. He states that this is able to convert quiescent cells into senescent cells. Besides, once this happens, there would be no molecular damage taking place. Such type of pathway already exists in yeasts along with other organisms that range from worms and may even include mammals. It is this pathway which drives developmental growth and can later drive aging along with various associated diseases. Follow Mikhail on Google Scholar
Here Dr. Mikhail Blagosklonny likes to state that he considers aging to be a useless run of several developmental programs, and it is entirely unintentional too. The cellular senescence will also refer to cell growth that is continuing. Hence he feels that over-stimulation in such cases has the potential to lead towards an increase in various functions. This may include secretion by fibroblasts, along with the contraction of the smooth arterial muscle cells. It would also include the aggregation of platelets. Other function can be the bone resorption through the osteoclasts, and the lipogenesis which is done by the fat cells. Next is the glycogenesis which is done by the liver cells. Other functions include inflammation which is done by neutrophils and the phagocytosis that is due to macrophages and so on. Any kind of overstimulation will lead to resisting of the cell signals. There can be many reasons for this. It can be as the signaling pathways are getting blocked.
This hyper-function and resistance to a signal can lead to several diseases, besides a loss of homeostasis, damage to organs and the eventual death of an organism. So the hyper-functioning of the arterial smooth muscle cells, and the macrophages and hepatocytes along with fat cells, besides blood platelets as well as neurons and the fibroblasts and many others have the potential to lead to several things. This includes blindness that is linked to age, besides gangrenes, as well as renal and heart failure. It may even lead to cancer. Visit classroomvoices.org to read more about Mikhail.
Now hyper-function can lead to chronic inflammation too, as suggested by Dr. Mikhail Blagosklonny. He says that this is closely linked to aging and other diseases that are related to age. This way Dr. Mikhail Blagosklonny has established that cellular hyper-function is one of the main culprits behind aging. This means that there is a need to look at various anti-aging agents. This would means looking at drugs like rapamycin and metformin and so on.
This is a major theory postulated by Dr. Mikhail Blagosklonny which scientists all over are working upon.